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Premier Research Labs
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Premier Glucose Manager™ by Premier Research Labs is a practitioner-grade blood sugar support formula combining GlucoVantage® Dihydroberberine (100 mg) and Reducose® Mulberry Leaf Extract (250 mg) to deliver dual-mechanism glycemic and metabolic support.* This clinically validated formula addresses both carbohydrate digestion in the gut and cellular glucose utilization for comprehensive blood sugar balance across the full glycemic cycle.*
Premier Glucose Manager™ by Premier Research Labs delivers a comprehensive, dual-mechanism approach to glycemic and metabolic support using two clinically validated ingredients at their scientifically substantiated doses.*
This advanced practitioner-grade formula pairs GlucoVantage® Dihydroberberine (100 mg) with Reducose® Mulberry Leaf Extract (250 mg, standardized to 12.5 mg DNJ) to address glucose regulation at both the intestinal and cellular levels, supporting balanced blood sugar responses across the full glycemic cycle.*
Unlike conventional glucose formulas that target only one pathway, Glucose Manager™ supports both carbohydrate digestion and cellular glucose utilization, offering complete metabolic coverage before and after meals.*
Most glucose support supplements focus on either slowing carbohydrate absorption or improving insulin sensitivity. Glucose Manager™ uniquely combines both strategies in a single formula, helping to moderate post-meal glucose excursions while enhancing cellular energy metabolism and insulin signaling.*
This professional-grade formulation features two clinically-validated ingredients, each supported by human clinical research and delivered at evidence-based doses for reliable, repeatable results.*
GlucoVantage® represents a next-generation advancement in berberine supplementation. As a hydrogenated derivative of berberine, dihydroberberine (DHB) delivers up to 5× greater bioavailability than standard berberine, allowing for enhanced effectiveness at lower doses and improved tolerability.*
How It Works:
DHB activates AMPK, often referred to as the body's "master metabolic switch." This activation supports insulin sensitivity, promotes healthy cellular glucose uptake, and enhances mitochondrial energy production in muscle and liver tissue.* With a sustained half-life of approximately 4–6 hours, DHB provides extended metabolic support throughout the day.*
Key Benefits:
Reducose® is a premium mulberry leaf extract standardized to 5% 1-Deoxynojirimycin (DNJ), delivering 12.5 mg DNJ per dose — up to 50× more DNJ than typical mulberry extracts. Its efficacy is supported by more than a decade of human clinical research.*
How It Works:
DNJ naturally inhibits alpha-glucosidase enzymes in the small intestine, slowing the breakdown of complex carbohydrates into simple sugars. This action helps smooth post-meal glucose curves, reduce insulin demand, and convert high-glycemic foods into lower-glycemic equivalents.*
Key Benefits:
| Feature | Single-Ingredient Glucose Products | Standard Berberine | Glucose Manager™ |
|---|---|---|---|
| Dual-Mechanism Glucose Support* | Minimal None | Minimal None | Strong Clinically Supported |
| Supports Post-Meal Glucose Control* | Moderate Limited | Moderate Limited | Strong Clinically Supported |
| Supports Insulin Sensitivity* | Moderate Limited | Moderate Limited | Strong Clinically Supported |
| AMPK Activation & Cellular Energy Support* | Minimal None | Moderate Limited | Strong Clinically Supported |
| Clinically Validated Bioavailability* | Minimal None | Minimal None | Strong Clinically Supported (5× vs. berberine)1 |
| Evidence-Based Ingredient Dosing* | Moderate Limited | Moderate Limited | Strong Clinically Supported |
| Reduced GI Discomfort vs. Berberine* | Moderate Limited | Minimal None | Strong Clinically Supported |
| Solvent-Free, Clean Extraction Methods* | Moderate Limited | Moderate Limited | Strong Clinically Supported |
| Practitioner-Grade Formulation* | Moderate Limited | Moderate Limited | Strong Clinically Supported |
No synthetic additives, harsh solvents, or unnecessary excipients.*
Verified for identity, purity, potency, and microbiological safety to ensure uncompromised practitioner-grade quality.*
Download the Product Information Sheet
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Unit Size: 60 Capsules
Contraindications: If you are taking glucose-lowering medications, consult your healthcare provider before use, as this product may have additive effects. Dihydroberberine may interact with medications metabolized by CYP450 enzymes or P-glycoprotein. Not recommended during pregnancy or lactation. Keep out of reach of children. Consult your health care practitioner if you are pregnant or nursing, taking medications or have a medical condition, before taking this or any other product. Use only if tamper seal is intact. Store in a cool, dry place.
Ingredients
IngredientLatin Botanical NameAmount Per ServingGlucoVantage® (Dihydroberberine)—100 mgReducose® Mulberry Leaf Extract (standardized to contain 5% 1-deoxynojirimycin)Morus alba250 mgOther Ingredients: Plant-Source Capsule (cellulose, water), Rice Bran (Non-GMO)Serving Size: 1 Capsule | Servings Per Container: 60†Daily Value Not EstablishedReducose® is a trademark of Phynova. GlucoVantage® is a registered trademark of NNB Nutrition. Patented — see nnbnutrition.com/patents
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