Phyto-4

Verifiable Science

Perluxan^® is a clinically studied extract of hops specifically developed to promote joint health. In a randomized, double-blind, placebo-controlled trial of 36 subjects, the benefits of Perluxan^® on joint comfort reached statistical significance within two hours of the first dose and were sustained over the 14-day period. Perluxan^® is free of sleep-inducing and phytoestrogenic compounds typically associated with hops extracts.¹ The alpha and iso-alpha acids in Perluxan^® maintain healthy NF-kappa B-associated expression of COX-2 and cytokines such as IL-6 and TNFα in connective tissue.² Curcumin complements Perluxan^® through its extensively characterized effects on cytokine-mediated signal transduction, matrix metalloproteinase (MMP) expression and multiple components of the arachidonic acid cascade.³ Curcumin C3 Complex^® is the subject of extensive ongoing clinical investigations at numerous hospitals and universities.⁴ Ginger promotes joint health through maintaining healthy cytokine signaling in cartilage and the synovium.⁵ 5LOXIN^®Boswellia serrata extract provides the highly bioactive triterpenoid AKBA, which supports connective tissue structural composition and comfort through supporting healthy immune responses, 5-lipoxygenase activity and synovial matrix metalloproteinase 3 (MMP-3) levels.^6,7 In a 3-month double-blind, placebo-controlled study of 75 subjects, significant functional support and comfort scores were evident as early as day 7.^8*