Bio Folic Acid + B12 Liquid

Vegan-friendly combination of B vitamins
• Helps the body to form red blood cells and to metabolize nutrients
• Helps to reduce the risk of neural tube defects when taken daily at least three months prior to becoming pregnant and during early pregnancy
• Provides 400 mcg of folic acid and 125 mcg of vitamin B₁₂ per 8 drops
• Delicious natural cherry flavour

Bio Folic Acid + B₁₂ Liquid is a vegan-friendly option that helps to prevent vitamin B₁₂ deficiency among vegetarian and vegans, whose diets tend to provide inadequate levels of vitamin B₁₂.¹ Both vitamin B₁₂ and folic acid are involved in red blood cell formation and DNA synthesis.^2,3 Vitamin B₁₂ and folic acid are also required for the conversion of homocysteine to methionine, which is necessary for the production of S-adenosyl-methionine, the methyl donor involved in nearly all methylation reactions.^4,5 Research demonstrates that daily supplementation with 400 mcg of folic acid during the first trimester helps to decrease neural tube defects by approximately 50%.⁶ In a randomized, placebo-controlled trial involving 119 pregnant women, continued supplementation with 400 mcg of folic acid daily into the second and third trimesters significantly increased maternal and cord blood folate status.⁷ Folic acid intake also better maintained homocysteine levels in the late stages of pregnancy, which may be associated with appropriate methyl transfer activity.^5,7

References
1. Briani, C, Dalla Torre, C, Citton, V, Manara, R, Pompanin, S, Binotto, G, Adami, F. Nutrients. 2013; 5: 4521-4539.
2. Fenech, M. Mutation Research. 2012; 733: 21- 33.
3. Combs, GF. (2012). The Vitamins. USA: Elsevier.
4. Czeizel, AE, Dudàs, I, Vereczkey, A, Bànhidy, F. Nutrients. 2013; 5: 4760-4775.
5. Imbard, A, Benoist, JF, Blom, HJ. Int. J. Environ. Res. Public Health. 2013; 10: 4352-4389.
6. Osterhues, A, Ali, NS, Michels, KB.  Critical Reviews in Food Science and Nutrition. 2013; 53: 1180-1190.
7. McNulty, B, McNulty, H, Marshall, B, Ward, M, Molloy, AM, Scott, JM, Dornan, J, Pentieva, K. Am J Clin Nutr. 2013; 98: 92-98.