HMF Metabolic

• Assists in weight management when used with a program of reduced intake of dietary calories and increased physical activity
• Includes a combination of five proprietary human strains clinically studied in adults
• Supports gastrointestinal health and promotes a favourable gut flora
• Provides 50 billion CFU per capsule

HMF^® Metabolic was specifically formulated with a combination of five proprietary probiotic strains, which were studied in a recent randomized, double-blind, placebo-controlled trial in adults.1 Results of the study demonstrated that HMF^® Metabolic’s probiotic strains significantly increased quality of life scores, including general wellness and state of health.¹ These strains have also been examined in various other preclinical and clinical studies for their beneficial health effects, including their ability to promote a healthy gut flora composition.^2-6 Emerging research demonstrates that diet and weight play an important role in the composition of the intestinal microflora, with the typical Western diet and larger body composition being associated with a greater proportion of Firmicutes than Bacteroidetes.⁷ These alterations in the normal gut flora composition may impact intestinal function, including short-chain fatty acid production and energy metabolism.⁸ Available in a convenient, once-daily capsule format, HMF^® Metabolic can be easily added to any lifestyle regimen to support an optimal gut flora composition and assist in weight management when used with a program of reduced intake of dietary calories and increased physical activity.

REFERENCES
1. Michael DR, Jack AA, Masetti G, Davies TS, Loxley KE, et al. Sci Rep. 2020 Mar; 10(1): 4183.
2. Michael DR, Moss JW, Calvente DL, Garaiova I, Plummer SF, et al. Benef Microbes. 2016 Jun; 7(3): 443-51.
3. Michael DR, Davies TS, Moss JWE, Calvente DL, Ramji DP, et al. Sci Rep. 2017 Jun; 7(1):2883.
4. Williams EA, Stimpson J, Wang D, Plummer S, Garaiova I, et al. Aliment Pharmacol Ther. 2009 Jan; 29(1): 97-103.
5. Madden JA, Plummer SF, Tang J, Garaiova I, Plummer NT, et al. Int Immunopharmacol. 2005 Jun; 5(6): 1091-7.
6. Plummer SF, Garaiova I, Sarvotham T, Cottrel, SL, Le Scouiller S, et al. Int J Antimicrob Agents. 2005 Jul; 26(1): 69-74.
7. Kobyliak N, Conte C, Cammarota G, Haley AP, Styriak I, et al. Nutr Metab (Lond). 2016 Feb; 13:14.
8. Cerdó T, García-Santos JA, G Bermúdez M, Campoy C. Nutrients. 2019 Mar; 11(3): 635.