HMF Replenish Capsules

Reduces symptoms of IBS in adults and children
• Provides live microorganisms that form part of a natural healthy gut flora
• Proven to supplement the normal intestinal microbiota following antibiotic therapy
• Probiotics to significantly reduce symptoms of irritable bowel syndrome (IBS) in adult and children over 11 years
•  Provides 100 billion CFU per dose from: Lactobacillus acidophilus (CUL-60), Lactobacillus acidophilus (CUL-21), Bifidobacterium bifidum (CUL-20), Bifidobacterium animalis subsp. lactis (CUL-34), Lactobacillus salivarius (CUL-61)
• Includes fructooligosaccharides (FOS)

HMF Replenish Capsules contain five strains of proprietary human-sourced probiotics that decrease IBS symptoms in adults and children. IBS affects nearly 5 million Canadians and can result from altered intestinal microflora.^1,2 Lactobacilli and Bifidobacteria promote healthy intestinal microflora and increase the reabsorption of bile salts, which is impaired in IBS.¹ This results in less water entering the colon to dilute the bile salts, decreasing water excretion and the occurrence of diarrhea.¹ In a randomized, placebo-controlled trial involving 52 adults with IBS, daily supplementation with CUL-60, CUL-21, CUL-20 and CUL-34 significantly improved quality of life and bowel habit satisfaction scores, and decreased the number of days with pain within 10 weeks.³ Antibiotics also alter intestinal microflora, and can result in the proliferation of antibiotic-resistant bacteria.¹ HMF Replenish Capsules promote normal intestinal microbiota following antibiotic therapy by further decreasing the pH and increasing mucin release to prevent pathogenic adherence to cells.^4,5

REFERENCES
1. Sarowska, J, Choroszy-Król, I, Regulska-Ilow, B, Frej-Madrzak, M, Jama-Kmiecik, A. Adv Clin Exp Med. 2013; 22(5): 759-766.
2. Fedorak, RN, Vanner, SJ, Paterson, WG, Bridges, RJ. Can J Gastroenterol. 2012; 26(5): 252-256.
3. Williams, EA, Stimpson, J, Wang, D, Plummer, S, Garaiova, I, Barker, ME, Corfe, BM. Aliment Pharmacol Ther. 2008; 29: 97-103.
4. Nagpal, R, Yadav, H, Kumar, M, Jain, S, Yamashiro, Y, Marotta, F. (2013). In Otles, S. (Ed.), Probiotics and Prebiotics in Food, Nutrition and Health (pp. 1-24). Boca Raton, FL: CRC Press.
5. Saulnier, N, Zocco, MA, Di Caro, S, Gasbarrini, G, Gasbarrini, A. Genes & Nutrition. 2006; 1(2): 107-116.